Nano-enabled biosensing systems for intelligent healthcare: towards COVID-19 management

Biosensors are emerging as efficient (sensitive and selective) and affordable analytical diagnostic tools for early-stage disease detection, as required for personalized health wellness management. Low-level detection of a targeted disease biomarker (pM level) has emerged extremely useful to evaluate the progression of disease under therapy. Such collected bioinformatics and its multi-aspects-oriented analytics is in demand to explore the effectiveness of a prescribed treatment, optimize therapy, and correlate biomarker level with disease pathogenesis. Owing to nanotechnology-enabled advancements in sensing unit fabrication, device integration, interfacing, packaging, and sensing performance at point-of-care (POC) has rendered diagnostics according to the requirements of disease management and patient disease profile i.e. in a personalized manner. Efforts are continuously being made to promote the state of art biosensing technology as a next-generation non-invasive disease diagnostics methodology. Keeping this in view, this progressive opinion article describes personalized health care management related analytical tools which can provide access to better health for everyone, with overreaching aim to manage healthy tomorrow timely. Considering accomplishments and predictions, such affordable intelligent diagnostics tools are urgently required to manage COVID-19 pandemic, a life-threatening respiratory infectious disease, where a rapid, selective and sensitive detection of human beta severe acute respiratory system coronavirus (SARS-COoV-2) protein is the key factor.     

基于投影寻踪分类模型的高管团队战略协同分析

着眼于企业高管团队战略协同系统所蕴含的学术与实践价值,研究系统效能重于高管团队自身的作为,关注系统优化则更重于传统模式下高管团队的内部建设.本文首先探究了高管团队与企业战略的协同机理;然后将基于实码加速遗传算法的投影寻踪分类模型技术引入子系统及子系统序参量的权重计算和有序度评价,提出了新的协同度评价方法,建立了高管团队的战略协同度评价模型;应用该模型对S企业进行了实例研究,印证了模型的可操作性.企业高管团队的战略协同度评价结果有助于识别具体企业高管团队战略协同进程中的制约要素,从而有针对性地提出优化对策.     

基于未确知测度理论的工业企业经济效益评价

介绍了工业企业经济效益评价的经济指标,建立了基于未确知测度理论的多属性综合评价方法.在确定各评价对象的属性权重时,采用熵值法这一客观性方法来确定.通过实例,将这种方法应用于具体的工业企业经济效益的评价,为评价企业经济效益提供了一种量化处理的方法,从而能够更直观、更合理地分析评价企业的经济效益状况.     

地铁车站火灾风险的模糊综合评价

根据地铁车站火灾的特点,确定地铁车站火灾风险的评价指标体系及权重.运用模糊数学原理,建立地铁车站火灾风险的模糊综合评价模型,并应用模型对某地铁车站火灾风险进行评价,较好的反映该地铁车站火灾安全的实际状况.方法为地铁车站火灾风险评价提供了新的思路,也为地铁车站火灾的防治提供理论依据.     

口腔医院系统发展对策生成与对策效应定量仿真评价

医院系统是一个复杂系统.对此,采用对策生成与对策实施未来效应仿真评价法对南昌大学口腔医院发展进行研究.首先,对南昌大学口腔医院发展进行了深入调查与数据分析,然后,建立7个增长正反馈环和4个制约负反馈环构成的增长制约反馈基模,揭示现行系统发展的优势和存在的问题,又围绕7个增长正反馈环和4个制约负反馈环的内涵,依据消除制约的原理,提出了消除负反馈环制约的两项管理对策.接着,对管理对策未来实施效应进行仿真评价,基于评价指标建立流位流率系,基于调查数据值及比较分析建立七棵入树的仿真方程,建立仿真模型,分别对南昌大学口腔医院系统发展两项对策实施状况进行仿真评价,定量论证了所制定的管理对策的科学性及实施的必要性,为南昌大学口腔医院十二五规划编制与发展提供了决策依据.     

规定安全间隔的CNS性能环境研究

对平行航路下规定安全间隔的CNS性能环境评估问题进行了研究.首先分析了CNS性能环境对飞机碰撞风险的影响,并结合Reich模型和概率论方法建立了CNS性能环境下飞机纵向、侧向和垂直方向上的碰撞风险模型;其次对碰撞风险模型进行分析转化得到了规定的安全间隔和安全目标水平下CNS性能环境的评估计算方法.最后对平行航路的CNS性能环境进行了评估计算,得到符合航路安全目标水平1.5×10~(-8)的CNS性能环境为RNP10、RCP400、RSP20.     

基于统计过程控制技术的项目管理可视化控制系统

概述IMCS-SPC模型的总体框架、组成部分以及两大核心技术(多变量统计过程控制技术和虚拟现实可视化技术);详细讨论项目管理者构建IMCS-SPC模型的基本步骤。作为一种采用多元统计分析进行过程控制的可视化决策支持系统,IMCS-SPC为项目管理者提供了一种十分清晰、直观的过程控制方法和工具,可有效提高项目管理效率,以确保项目过程的正常运行。     

Fuzzy goal programming for inventory management: A bacterial foraging approach

An efficient inventory planning approach in today’s global trading regime is necessary not only for increasing the profit margin, but also to maintain system flexibility for achieving higher customer satisfaction. Such an approach should hence be comprised of a prudent inventory policy and clear satisfaction of stakeholder’s goals. Relative significance given to various objectives in a supply chain network varies with product as well as time. In this paper, a model is proposed to fill this void for a single product inventory control of a supply chain consisting of three echelons. A generic modification proposed to the membership functions of the fuzzy goal-programming approach is used to mathematically map the aspiration levels of the decision maker. The bacterial foraging algorithm has been modified with enhancement of the algorithms’ capability to map integer solution spaces and utilised to solve resulting fuzzy multi-objective function. An illustrative example comprehensively covers various decision scenarios and highlights the underlying managerial insights.     

Time-cost trade-off analysis of project networks in fuzzy environments

This paper proposes a novel approach for time-cost trade-off analysis of a project network in fuzzy environments. Different from the results of previous studies, in this paper the membership function of the fuzzy minimum total crash cost is constructed based on Zadeh’s extension principle and fuzzy solutions are provided. A pair of two-level mathematical programs parameterized by possibility level α is formulated to calculate the lower and upper bounds of the fuzzy minimum total crash cost at α. By enumerating different values of α, the membership function of the fuzzy minimum total crash cost is constructed, and the corresponding optimal activity time for each activity is also obtained at the same time. An example of time-cost trade-off problem with several fuzzy parameters is solved successfully to demonstrate the validity of the proposed approach. Since the minimum total crash cost is expressed by a membership function rather than by a crisp value, the fuzziness of parameters is conserved completely, and more information is provided for time-cost trade-off analysis in project management. The proposed approach also can be applied to time-cost trade-off problems with other characteristics.     

Coordinating a decentralized supply chain with customer returns and price-dependent stochastic demand using a buyback policy

We investigate a decentralized supply chain that consists of a manufacturer and a retailer where the retailer simultaneously determines the retail price and order quantity while experiencing customer returns and price dependent stochastic demand. We propose an agreement between the manufacturer and the retailer that includes two buyback prices, one for unsold inventory and a second for customer returns, and show that this type of easy-to-implement agreement can achieve perfect supply chain coordination and be a win-win for both manufacturer and retailer when a complementary profit-sharing agreement is included.